Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PPARG | P37231 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28000410 | 0.79 | ALDH1A1 (0.60) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL17871939 | 0.78 | KDM4E (0.58) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL27926206 | 0.76 | LMNA (0.38) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL25229706 | 0.75 | KDM4E (0.55) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL20421204 | 0.74 | KDM4E (0.54) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL28000229 | 0.74 | KDM4E (0.54) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL20421209 | 0.73 | KDM4E (0.53) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| Tert-Butyl Formate SCHEMBL27926207 | 0.72 | MAP2K4 (0.38) | TDP1NTRK1GABRA1GABRG2GABRB3 | |
| SCHEMBL18691011 | 0.71 | ALDH1A1 (0.51) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL17871778 | 0.71 | ALDH1A1 (0.50) | KDM4EHPGDHSD17B10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103429585-B | Indazolyl triazole derivatives as interleukin-1 receptor associated kinase inhibitors | MERCK SERONO SA | 2015-07-08 | — | — | CN | disclosed |
| CN-103429585-A | Indazolyl triazole derivatives as interleukin-1 receptor associated kinase inhibitors | MERCK SERONO SA | 2013-12-04 | — | — | CN | disclosed |