Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27945213 | 0.85 | RAB9A (0.36) | LMNARAB9ASMN1; SMN2HSD17B10MAPK10 | |
| SCHEMBL27945216 | 0.76 | KDM4E (0.54) | LMNAHSD17B10NTRK1GABRA1GABRG2 | |
| Tert-Butyl Formate SCHEMBL27926207 | 0.75 | MAP2K4 (0.38) | NTRK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL27926231 | 0.71 | TLR7 (0.36) | — | |
| SCHEMBL27811452 | 0.71 | MAP2K4 (0.52) | LMNARAB9ASMN1; SMN2HSD17B10MAPK10 | |
| SCHEMBL27926203 | 0.70 | KDM4E (0.49) | LMNARAB9ASMN1; SMN2HSD17B10MAPK10 | |
| SCHEMBL27945214 | 0.69 | HTR1D (0.42) | LMNAKDM4EGAAGLAHTT | |
| SCHEMBL27305897 | 0.69 | ELANE (0.52) | RAB9ASMN1; SMN2NPC1KDM4EMAPT | |
| SCHEMBL28290004 | 0.68 | ENPP2 (0.49) | KDM4EMAPTALDH1A1GAAPKM | |
| SCHEMBL13811550 | 0.68 | MAOB (0.54) | LMNARAB9ASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103429585-B | Indazolyl triazole derivatives as interleukin-1 receptor associated kinase inhibitors | MERCK SERONO SA | 2015-07-08 | — | — | CN | disclosed |
| CN-103429585-A | Indazolyl triazole derivatives as interleukin-1 receptor associated kinase inhibitors | MERCK SERONO SA | 2013-12-04 | — | — | CN | disclosed |