Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15118223 | 0.89 | LTA4H (0.48) | LTA4HSIGMAR1SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL2300940 | 0.82 | LTA4H (0.53) | LTA4HALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL12486958 | 0.82 | LTA4H (0.58) | LTA4HALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL211606 | 0.81 | LTA4H (0.77) | LTA4HSIGMAR1ALDH1A1MEN1MAPT | |
| SCHEMBL9122265 | 0.81 | LTA4H (0.77) | LTA4HSIGMAR1ALDH1A1MEN1MAPT | |
| SCHEMBL9097701 | 0.80 | LTA4H (0.66) | LTA4HSIGMAR1HTR1AALDH1A1MEN1 | |
| SCHEMBL3154476 | 0.80 | HRH3 (0.57) | LTA4HALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL15986145 | 0.80 | CHRNB2 (0.54) | — | |
| SCHEMBL5752269 | 0.79 | LTA4H (0.64) | LTA4HALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL22266155 | 0.78 | LTA4H (0.62) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103420940-B | Aralkyl naphthenic aminopiperazine derivatives and applications thereof as multi-targeted antidepressant | SHANGHAI INST PHARM INDUSTRY | 2014-09-17 | — | — | CN | disclosed |
| CN-103420940-A | Aralkyl naphthenic aminopiperazine derivatives and applications thereof as multi-targeted antidepressant | SHANGHAI INST PHARM INDUSTRY | 2013-12-04 | — | — | CN | disclosed |