Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.59 |
| ▸ | BRD4 | O60885 | 7/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | QDPR | P09417 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10566304 | 0.85 | ERN1 (0.59) | ERN1BRD4MAPTKMT2AHSD17B10 | |
| SCHEMBL1527140 | 0.74 | ERN1 (1.00) | ERN1 | |
| SCHEMBL28937901 | 0.74 | ERN1 (0.49) | ERN1BRD4ESR2MEN1MAPT | |
| SCHEMBL10565642 | 0.71 | PRKCA (0.44) | ERN1BRD4MEN1MAPTKMT2A | |
| SCHEMBL3693339 | 0.69 | MAOB (0.67) | MAOBQDPRMEN1LMNAMAPT | |
| SCHEMBL28937876 | 0.69 | BRD4 (0.44) | ERN1BRD4MEN1LMNAMAPT | |
| Formaldehyde SCHEMBL27695423 | 0.68 | MAOB (0.87) | MAOBMEN1MAPTHPGDKMT2A | |
| SCHEMBL25980029 | 0.68 | ERN1 (0.47) | ERN1LMNAMAPTALOX15KMT2A | |
| SCHEMBL28937905 | 0.67 | KMT2A (0.47) | ERN1BRD4MAPTKMT2AHSD17B10 | |
| SCHEMBL28937852 | 0.67 | MAPT (0.43) | ERN1BRD4MAOBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103450077-A | IRE-1A inhibitors | MANNKIND CORP | 2013-12-18 | — | — | CN | disclosed |