Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 6/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10566304 | 0.85 | ERN1 (0.59) | PRKCAGSK3BERN1BRD4BRD9 | |
| SCHEMBL10565550 | 0.76 | KIT (0.44) | TDP2NPC1L3MBTL1GAAALDH1A1 | |
| SCHEMBL11434073 | 0.72 | L3MBTL1 (0.47) | PRKCAGSK3BBRD4BRD9NPC1 | |
| Formaldehyde SCHEMBL27945893 | 0.71 | ERN1 (0.59) | ERN1BRD4BRD9GAAALDH1A1 | |
| SCHEMBL10567603 | 0.71 | KDM4E (0.42) | BRD9TDP2NPC1L3MBTL1GAA | |
| SCHEMBL22289953 | 0.70 | BRD4 (0.59) | PRKCAGSK3BBRD4BRD9 | |
| SCHEMBL10568294 | 0.67 | TSHR (0.50) | TDP2L3MBTL1GAAALDH1A1TSHR | |
| SCHEMBL11434447 | 0.67 | GAK (0.48) | PRKCAGSK3BNPC1L3MBTL1GAA | |
| SCHEMBL10732075 | 0.67 | THRB (0.44) | TDP2ALDH1A1TSHRHTTHSD17B10 | |
| SCHEMBL28705161 | 0.66 | MAPT (0.50) | NPC1L3MBTL1ALDH1A1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824851-A | Pyrimidones as cardiotonic, anti hypertensive, cerebrovascular vasodilator and anti-platelet agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0123402-B1 | PYRIMIDINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |
| US-4746664-A | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-24 | — | — | US | disclosed |
| US-4612376-A | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-09-16 | — | — | US | disclosed |
| EP-0123402-A2 | Pyrimidine derivatives, preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-31 | — | — | EP | disclosed |