Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | GLA | P06280 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | TNKS2 | Q9H2K2 | 8/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5993711 | 0.86 | KDM4E (0.59) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL9724162 | 0.83 | LMNA (0.67) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL31475465 | 0.83 | LMNA (0.67) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL8109985 | 0.82 | KDM4E (0.59) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL29894052 | 0.81 | KDM4E (0.59) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL4736477 | 0.81 | KDM4E (0.59) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL1378769 | 0.80 | TNKS2 (0.75) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL2798886 | 0.80 | KDM4E (0.62) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL8873180 | 0.80 | CA12 (0.56) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL592109 | 0.80 | KDM4E (1.00) | KDM4EGLAGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108503582-B | Microwave-assisted synthesis method of 2- (1H) -quinolinone compounds | 湖南科技学院 | 2020-01-07 | — | — | CN | disclosed |
| CN-108503582-A | The microwave assisted synthesizing method of 2- (1H)-quinolinones compound | 湖南科技学院 | 2018-09-07 | — | — | CN | disclosed |
| US-20170016907-A1 | DUAL-SENSITIZER-CONTAINING LUMINESCENT COMPOUNDS, CONJUGATES, AND USES THEREOF | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-01-19 | — | — | US | disclosed |
| US-9415111-B2 | Dual-sensitizer-containing luminescent compounds, conjugates, and uses thereof | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-08-16 | — | — | US | disclosed |
| US-8653069-B2 | Aralkyl substituted piperidine or piperazine derivatives and their use for treating schizophrenia | JIANGSU HENGYI PHARMACEUTICAL CO., LTD. (CN) | 2014-02-18 | — | — | US | disclosed |
| US-8524738-B2 | Quinolinones and quinoxalinones as antibacterial composition | TOYAMA CHEMICAL CO., LTD. (JP) | 2013-09-03 | — | — | US | disclosed |
| US-8524738-B2 | Quinolinones and quinoxalinones as antibacterial composition | TOYAMA CHEMICAL CO., LTD. (JP) | 2013-09-03 | — | — | US | disclosed |
| US-8329694-B2 | Quinoxalinones as antibacterial composition | TOYAMA CHEMICAL CO., LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-8329694-B2 | Quinoxalinones as antibacterial composition | TOYAMA CHEMICAL CO., LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-8329694-B2 | Quinoxalinones as antibacterial composition | TOYAMA CHEMICAL CO., LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-20100168418-A1 | NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2010-07-01 | — | — | US | disclosed |
| US-20100168418-A1 | NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2010-07-01 | — | — | US | disclosed |
| US-7655688-B2 | Treating nuclear hormone receptor-associated conditions such as cancer and immune disorders; (3a alpha ,4 alpha ,7 alpha ,7a alpha )-2-(3-Chloro-4-hydroxyphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| US-7655688-B2 | Treating nuclear hormone receptor-associated conditions such as cancer and immune disorders; (3a alpha ,4 alpha ,7 alpha ,7a alpha )-2-(3-Chloro-4-hydroxyphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| US-7632651-B2 | Molecular modification assays | MDS ANALYTICAL TECHNOLOGIES (US) INC. (US) | 2009-12-15 | — | — | US | disclosed |
| US-7632651-B2 | Molecular modification assays | MDS ANALYTICAL TECHNOLOGIES (US) INC. (US) | 2009-12-15 | — | — | US | disclosed |
| EP-1900732-A1 | NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |
| US-4187310-A | ANTIINFLAMMATORY AGENT, ANALGESICS, ENZYME INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-02-05 | — | — | US | disclosed |
| US-4138490-A | Analgesic compositions containing 1,2-dihydro-2-oxoquinol-4-ylpropionic acid derivatives | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168418-A1 | NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF | ROS1, NOX1, ARG1 | KDM4E 2360/4885GLA 3562/4885GAA 4764/4885 |
| US-20170016907-A1 | DUAL-SENSITIZER-CONTAINING LUMINESCENT COMPOUNDS, CONJUGATES, AND USES THEREOF | DYRK4, DYRK2, DYRK3 | KDM4E 2347/4885GLA 1328/4885GAA 473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.