Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylphenylsulfone SCHEMBL78253 | 0.87 | PTGS2 (0.62) | PTGS2ENPP2TSHRSMN1; SMN2HTR6 | |
| Methylphenylsulfone SCHEMBL1332357 | 0.87 | PTGS2 (0.62) | PTGS2ENPP2TSHRSMN1; SMN2HTR6 | |
| Methylphenylsulfone SCHEMBL11042562 | 0.86 | PTGS2 (0.52) | PTGS2ENPP2AKR1C2AKR1C1AKR1C3 | |
| Methylphenylsulfone SCHEMBL5499087 | 0.85 | PTGS2 (0.60) | PTGS2ENPP2TSHRSMN1; SMN2HTR6 | |
| Methylphenylsulfone SCHEMBL28288197 | 0.83 | PTGS2 (0.54) | PTGS2ENPP2TSHRSMN1; SMN2HTR6 | |
| Methylphenylsulfone SCHEMBL29122782 | 0.83 | PTGS2 (0.59) | PTGS2ENPP2HTR6 | |
| Methylphenylsulfone SCHEMBL561404 | 0.83 | PTGS2 (0.54) | PTGS2ENPP2AKR1C2AKR1C1AKR1C3 | |
| Methylphenylsulfone SCHEMBL28046614 | 0.82 | PTGS2 (0.58) | PTGS2ENPP2TSHRSMN1; SMN2HTR6 | |
| Methylphenylsulfone SCHEMBL28158010 | 0.82 | PTGS2 (0.58) | PTGS2ENPP2TSHRSMN1; SMN2HTR6 | |
| Methylphenylsulfone SCHEMBL28288198 | 0.82 | PTGS2 (0.58) | PTGS2ENPP2TSHRSMN1; SMN2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103958495-A | Novel compounds as modulators of GPR-119 | RHIZEN PHARMACEUTICALS SA | 2014-07-30 | — | — | CN | disclosed |