Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | GLA | P06280 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27965321 | 0.83 | JAK2 (0.56) | SMN1; SMN2MEN1KMT2ATAAR1NPC1 | |
| SCHEMBL3612334 | 0.76 | RAB9A (0.54) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL13901755 | 0.74 | MAPT (0.79) | SMN1; SMN2ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL22862335 | 0.73 | TAAR1 (0.76) | SMN1; SMN2ALDH1A1MEN1KMT2ATAAR1 | |
| SCHEMBL14636633 | 0.72 | MEN1 (0.69) | SMN1; SMN2ALDH1A1GLAHTTMEN1 | |
| SCHEMBL30362638 | 0.72 | MEN1 (0.69) | SMN1; SMN2ALDH1A1GLAHTTMEN1 | |
| SCHEMBL4363732 | 0.72 | MEN1 (0.89) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL15463572 | 0.72 | HTT (0.70) | SMN1; SMN2ALDH1A1GLAHTTMEN1 | |
| SCHEMBL22130289 | 0.71 | — | — | |
| SCHEMBL27730037 | 0.71 | RAB9A (0.80) | SMN1; SMN2ALDH1A1GLAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103804367-B | Benzazepine derivant, Preparation Method And The Use | 天津药物研究院 | 2016-09-14 | — | — | CN | disclosed |
| CN-103804367-A | Benzodiazepine derivative, preparation method and use thereof | TIANJIN INST PHARM RESEARCH | 2014-05-21 | — | — | CN | disclosed |