SCHEMBL27965232

SCHEMBL27965232

O=C(Cc1ccccc1)N1CCN(C(=O)c2ccc(COc3ccccc3)cc2)CC1

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.66
MEN1 O00255 2/20 0.66
KMT2A Q03164 2/20 0.66
USP2 O75604 1/20 0.65
GAA P10253 1/20 0.65
SLC6A7 Q99884 1/20 0.63
NPC1 O15118 3/20 0.55
GPR183 P32249 2/20 0.55
RAB9A P51151 2/20 0.55
MAPT P10636 2/20 0.55
FAAH O00519 1/20 0.55
HPGD P15428 2/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
LMNA P02545 1/20 0.53
PKM P14618 1/20 0.53
MAPK1 P28482 1/20 0.53
NAAA Q02083 1/20 0.53
MGLL Q99685 1/20 0.53
KCNA5 P22460 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27965230 0.85 SLC6A7 (0.55) ALDH1A1MEN1KMT2AUSP2GAA
SCHEMBL27965288 0.84 KCNA5 (0.69) ALDH1A1KMT2AGAASLC6A7NPC1
SCHEMBL27964887 0.84 SLC6A7 (0.62) ALDH1A1MEN1KMT2ASLC6A7NPC1
SCHEMBL27964892 0.84 SIGMAR1 (0.63) ALDH1A1KMT2ASLC6A7NPC1RAB9A
SCHEMBL27965228 0.83 SMN1; SMN2 (0.75) ALDH1A1MEN1KMT2ASLC6A7NPC1
SCHEMBL1977856 0.82 SLC6A7 (0.70) ALDH1A1MEN1KMT2ASLC6A7NPC1
SCHEMBL5851806 0.82 SLC6A7 (0.66) ALDH1A1SLC6A7NPC1RAB9AMAPT
SCHEMBL15420889 0.81 NPC1 (0.76) ALDH1A1MEN1KMT2ASLC6A7NPC1
SCHEMBL27964896 0.81 SLC6A7 (0.59) ALDH1A1MEN1KMT2ASLC6A7NPC1
SCHEMBL1222159 0.81 USP2 (0.56) ALDH1A1MEN1KMT2AUSP2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103864722-A Synthesis and anti-cancer pharmaceutical effects of novel [4-(4-phenoxymethyl)benzoyl]piperazine derivatives UNIV TIANJIN SCIENCE & TECH 2014-06-18 CN claimed
CN-103864722-A Synthesis and anti-cancer pharmaceutical effects of novel [4-(4-phenoxymethyl)benzoyl]piperazine derivatives UNIV TIANJIN SCIENCE & TECH 2014-06-18 CN disclosed