Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | CASP3 | P42574 | 1/20 | 0.68 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.68 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.68 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | NAAA | Q02083 | 1/20 | 0.62 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.62 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15420889 | 0.96 | NPC1 (0.76) | SLC6A7ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL11081153 | 0.88 | SLC6A7 (0.61) | SLC6A7ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL5851806 | 0.87 | SLC6A7 (0.66) | SLC6A7ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL1169664 | 0.87 | HRH3 (0.61) | SLC6A7ALDH1A1NPC1RAB9AMAPT | |
| Ethylene SCHEMBL8377795 | 0.85 | SLC6A7 (0.63) | SLC6A7ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL4736708 | 0.84 | SLC6A7 (0.65) | SLC6A7ALDH1A1NPC1MAPTNAAA | |
| SCHEMBL27965228 | 0.83 | SMN1; SMN2 (0.75) | SLC6A7ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL27965232 | 0.82 | ALDH1A1 (0.66) | SLC6A7ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL15949477 | 0.82 | SLC6A7 (0.63) | SLC6A7ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL7519290 | 0.82 | SLC6A7 (0.63) | SLC6A7ALDH1A1NPC1MAPTNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609699-B2 | Oxotetrahydrofuran-2-yl-benzimidazole derivative | MSD K.K. (JP) | 2013-12-17 | — | — | US | disclosed |
| EP-2328892-B1 | OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-20110144162-A1 | OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-06-16 | — | — | US | disclosed |
| EP-2328892-A1 | OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE | MSD K.K. (JP) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010024110-A1 | OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144162-A1 | OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE | GCK, GCKR, KHK | SLC6A7 2534/4885ALDH1A1 823/4885NPC1 2556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.