Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 9/20 | 0.70 |
| ▸ | LPAR1 | Q92633 | 8/20 | 0.70 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.53 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.51 |
| ▸ | TLR2 | O60603 | 3/20 | 0.50 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LPAR6 | P43657 | 2/20 | 0.44 |
| ▸ | LPAR4 | Q99677 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL27966440 | 1.00 | LPAR3 (0.70) | LPAR3LPAR1LPAR2LPAR5TLR2 | |
| Monoethanolamine SCHEMBL27966443 | 1.00 | LPAR3 (0.70) | LPAR3LPAR1LPAR2LPAR5TLR2 | |
| Monoethanolamine SCHEMBL27966570 | 1.00 | LPAR3 (0.70) | LPAR3LPAR1LPAR2LPAR5TLR2 | |
| Monoethanolamine SCHEMBL27966448 | 0.95 | LPAR3 (0.61) | LPAR3LPAR1LPAR2LPAR5TLR2 | |
| SCHEMBL28150233 | 0.93 | LPAR3 (0.82) | LPAR3LPAR1LPAR2LPAR5RECQL | |
| SCHEMBL2232554 | 0.93 | LPAR3 (0.82) | LPAR3LPAR1LPAR2LPAR5RECQL | |
| SCHEMBL12345721 | 0.93 | LPAR3 (0.82) | LPAR3LPAR1LPAR2LPAR5RECQL | |
| Monoethanolamine SCHEMBL27411197 | 0.92 | LPAR3 (0.84) | LPAR3LPAR1LPAR2LPAR5TLR2 | |
| Monoethanolamine SCHEMBL27549117 | 0.92 | LPAR3 (0.84) | LPAR3LPAR1LPAR2LPAR5TLR2 | |
| Monoethanolamine SCHEMBL27635540 | 0.91 | LPAR3 (0.81) | LPAR3LPAR1LPAR2LPAR5TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103874485-B | FORMULATIONS AND DOSAGE FORMS OF OXIDIZED PHOSPHOLIPIDS | 脉管生物生长有限公司 | 2017-06-09 | — | — | CN | disclosed |
| CN-103874485-A | Formulations and dosage forms of oxidized phospholipids | VASCULAR BIOGENICS LTD | 2014-06-18 | — | — | CN | disclosed |