Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 12/20 | 0.84 |
| ▸ | LPAR1 | Q92633 | 11/20 | 0.84 |
| ▸ | LPAR2 | Q9HBW0 | 8/20 | 0.62 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.59 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.53 |
| ▸ | LPAR6 | P43657 | 5/20 | 0.51 |
| ▸ | LPAR4 | Q99677 | 5/20 | 0.51 |
| ▸ | TLR2 | O60603 | 4/20 | 0.51 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL27549117 | 1.00 | LPAR3 (0.84) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| Monoethanolamine SCHEMBL27635540 | 0.99 | LPAR3 (0.81) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| Monoethanolamine SCHEMBL29057722 | 0.93 | LPAR3 (0.72) | LPAR3LPAR1LPAR2LPAR5 | |
| Monoethanolamine SCHEMBL27966569 | 0.92 | LPAR3 (0.70) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| Monoethanolamine SCHEMBL27966570 | 0.92 | LPAR3 (0.70) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| Monoethanolamine SCHEMBL27966440 | 0.92 | LPAR3 (0.70) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| Alcohol SCHEMBL27915917 | 0.92 | LPAR3 (0.94) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| SCHEMBL2814732 | 0.92 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| SCHEMBL10896195 | 0.92 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| SCHEMBL31439420 | 0.92 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5PLA2G2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207433-A | New organic compound, the near infrared fluorescent contrast agent containing the compound and the method for preparing nano particle contrast agent | 车医科学大学校产学协力团 | 2017-09-26 | — | — | CN | claimed |
| CN-106456547-A | Encapsulation of messenger RNA | 夏尔人类遗传性治疗公司 | 2017-02-22 | — | — | CN | claimed |
| CN-105813656-A | LIPID FORMULATIONS FOR DELIVERY OF MESSENGER RNA | 夏尔人类遗传性治疗公司 | 2016-07-27 | — | — | CN | claimed |
| CN-105142676-A | CFTR MRNA compositions and related methods and uses | SHIRE HUMAN GENETIC THERAPIES | 2015-12-09 | — | — | CN | claimed |
| CN-100374165-C | Ultrasound contrast agents and process for the preparation thereof | BRACCO INT BV (NL) | 2008-03-12 | — | — | CN | claimed |
| CN-1744921-A | Ultrasonic contrast agent and preparation method thereof | BRACCO INT BV (NL) | 2006-03-08 | — | — | CN | claimed |
| CN-1102045-C | Novel compositions comprising lipids and stabilizers | IMARX PHARMACEUTICAL CORP (US) | 2003-02-26 | — | — | CN | claimed |
| CN-1180310-A | Novel compositions of lipids and stabilizing materials | IMARX PHARMACEUTICAL CORP (US) | 1998-04-29 | — | — | CN | claimed |
| CN-1160357-A | Gas filled microspheres as computed tomography contrast agents | IMARX PHARMACEUTICAL CORP (US) | 1997-09-24 | — | — | CN | claimed |
| CN-105377316-B | Method for preparing an object supporting a lipid bilayer | 利宝涂料私人有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-108024960-A | Pharmaceutical composition containing anionic drug and preparation method thereof | 株式会社三养生物制药 | 2018-05-11 | — | — | CN | disclosed |
| CN-107207433-A | New organic compound, the near infrared fluorescent contrast agent containing the compound and the method for preparing nano particle contrast agent | 车医科学大学校产学协力团 | 2017-09-26 | — | — | CN | disclosed |
| CN-106456546-A | Liposomal compositions for mucosal delivery | 葛兰素史密丝克莱恩生物有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106456547-A | Encapsulation of messenger RNA | 夏尔人类遗传性治疗公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-101005858-A | Gas-filled microbubble compositions for contrast imaging | BRACCO RESEARCH SA (CH) | 2007-07-25 | — | — | CN | disclosed |
| CN-1744921-A | Ultrasonic contrast agent and preparation method thereof | BRACCO INT BV (NL) | 2006-03-08 | — | — | CN | disclosed |
| CN-1444926-A | Bioadhesive Drug Delivery System | PHARMACEUTICAL TECHNOLOGY INC (US) | 2003-10-01 | — | — | CN | disclosed |
| CN-1102045-C | Novel compositions comprising lipids and stabilizers | IMARX PHARMACEUTICAL CORP (US) | 2003-02-26 | — | — | CN | disclosed |
| CN-1180310-A | Novel compositions of lipids and stabilizing materials | IMARX PHARMACEUTICAL CORP (US) | 1998-04-29 | — | — | CN | disclosed |
| CN-1160357-A | Gas filled microspheres as computed tomography contrast agents | IMARX PHARMACEUTICAL CORP (US) | 1997-09-24 | — | — | CN | disclosed |