Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 12/20 | 0.84 |
| ▸ | LPAR1 | Q92633 | 11/20 | 0.84 |
| ▸ | LPAR2 | Q9HBW0 | 8/20 | 0.62 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.59 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.53 |
| ▸ | LPAR6 | P43657 | 5/20 | 0.51 |
| ▸ | LPAR4 | Q99677 | 5/20 | 0.51 |
| ▸ | TLR2 | O60603 | 4/20 | 0.51 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL27411197 | 1.00 | LPAR3 (0.84) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| Monoethanolamine SCHEMBL27635540 | 0.99 | LPAR3 (0.81) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| Monoethanolamine SCHEMBL29057722 | 0.93 | LPAR3 (0.72) | LPAR3LPAR1LPAR2LPAR5 | |
| Monoethanolamine SCHEMBL27966569 | 0.92 | LPAR3 (0.70) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| Monoethanolamine SCHEMBL27966570 | 0.92 | LPAR3 (0.70) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| Monoethanolamine SCHEMBL27966440 | 0.92 | LPAR3 (0.70) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| Alcohol SCHEMBL27915917 | 0.92 | LPAR3 (0.94) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| SCHEMBL2814732 | 0.92 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| SCHEMBL10896195 | 0.92 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5PLA2G2C | |
| SCHEMBL31439420 | 0.92 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5PLA2G2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107614565-A | New fluorinated surfactant | RAN生物技术公司 | 2018-01-19 | — | — | CN | claimed |
| CN-107106708-A | MRI Imaging of Amyloid Plaques Using Liposomes | 德克萨斯州儿童医院 | 2017-08-29 | — | — | CN | claimed |
| CN-103394102-A | Lipid micro/nano bubble, and optimized preparation method and preparation device thereof | BOXIN BIOLOG TECHNOLOGY CO LTD | 2013-11-20 | — | — | CN | claimed |
| CN-109415723-A | IMPROVED PROMOTERS AND COMPOSITIONS | 牛津大学创新有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-104367997-B | Adjunvant composition comprising nonionic isotonic agent | 葛兰素史密丝克莱恩生物有限公司 | 2019-01-22 | — | — | CN | disclosed |
| CN-109152830-A | core/shell structure platform for immunotherapy | 卫理公会医院 | 2019-01-04 | — | — | CN | disclosed |
| CN-109071527-A | Cellular signal transduction inhibitor, their preparation and its method | 成事在人肿瘤学公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-103394102-B | Lipid micro/nano bubble, and optimized preparation method and preparation device thereof | 博信生物科技股份有限公司 | 2018-08-07 | — | — | CN | disclosed |
| CN-104703594-B | Stable aqueous dispersion of oxaliplatin-encapsulating liposomes and method for stabilizing same | 大鹏药品工业株式会社 | 2018-01-23 | — | — | CN | disclosed |
| CN-107530283-A | Combine liposomal pharmaceutical preparation | 奎尔波特股份有限公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-107530291-A | Dual-loading liposomal pharmaceutical formulations | 奎尔波特股份有限公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-102231952-A | Releasable cationic lipids for nucleic acids delivery systems | ENZON PHARMACEUTICALS INC | 2011-11-02 | — | — | CN | disclosed |
| CN-102202689-A | Vaccine | GLAXOSMITHKLINE BIOLOG SA | 2011-09-28 | — | — | CN | disclosed |
| CN-1859898-B | Compositions for delivering highly water soluble drugs | BEIJING YANGXIN TECHNOLOGY CO LTD | 2011-06-08 | — | — | CN | disclosed |
| CN-101829052-A | Self-emulsifying preparation of taxane compound and preparation method thereof | GUOQIANG WANG | 2010-09-15 | — | — | CN | disclosed |
| CN-101094646-A | Low oil emulsion compositions for delivering taxoids and other insoluble drugs | XIAN CHEN ANDREW (US) | 2007-12-26 | — | — | CN | disclosed |
| CN-100350981-C | Radioactive therapeutic Liposomes | ANTICANCER THERAPEUTIC INV SA (NO) | 2007-11-28 | — | — | CN | disclosed |
| CN-1859898-A | Compositions for delivering highly water soluble drugs | SD PHARMACEUTICALS INC (CN) | 2006-11-08 | — | — | CN | disclosed |
| CN-1404402-A | Radioactive therapeutic Liposomes | ANTICANCER THERAPEUTIC INV SA (NO) | 2003-03-19 | — | — | CN | disclosed |
| CN-1317977-A | Dry powder active agent pulmonary delivery | INHALE THERAPEUTIC SYST (US) | 2001-10-17 | — | — | CN | disclosed |