SCHEMBL27967474

SCHEMBL27967474

O=C(c1ccccc1-c1ccncn1)c1ccccc1-c1ccncn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP46A1 Q9Y6A2 3/20 0.50
CHRNB2 P17787 1/20 0.50
CHRNB4 P30926 1/20 0.50
CHRNA3 P32297 1/20 0.50
CHRNA4 P43681 1/20 0.50
CYP3A4 P08684 2/20 0.41
ALDH1A1 P00352 1/20 0.41
PDE10A Q9Y233 1/20 0.40
KDM4C Q9H3R0 1/20 0.39
KDR P35968 1/20 0.39
TEK Q02763 1/20 0.39
P2RX7 Q99572 1/20 0.38
CCNT1 O60563 1/20 0.38
CCNA2 P20248 1/20 0.38
CDK2 P24941 1/20 0.38
CDK9 P50750 1/20 0.38
CCNA1 P78396 1/20 0.38
CDK5 Q00535 1/20 0.38
CDK5R1 Q15078 1/20 0.38
ADORA2B P29275 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29525092 0.88 CHRNB2 (0.52) CYP46A1CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL7053092 0.88 CHRNB2 (0.52) CYP46A1CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL16654579 0.86 BCAT2 (0.53) CYP46A1CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL22728425 0.86 KDM4C (0.54) CYP46A1CHRNB2CHRNB4CHRNA3CHRNA4
Hydrochloric Acid SCHEMBL14840788 0.86 CHRNB2 (0.51) CYP46A1CHRNB2CHRNB4CHRNA3CHRNA4
Hydrochloric Acid SCHEMBL30692651 0.83 BCAT2 (0.50) CYP46A1CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL3826781 0.82 CHRNB2 (0.55) CYP46A1CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL14841044 0.82 SLC6A3 (0.51) CYP46A1CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL10601314 0.80 MAPK9 (0.43) CYP46A1CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL9202323 0.79 KDM4E (0.50) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103842356-B For treating 1 aryl carbonyl, the 4 Oxypertine compound of neurodegenerative disease 武田药品工业株式会社 2017-03-15 CN disclosed
CN-103842356-A 1 - arylcarbonyl - 4 - oxy - piperidine compounds useful for the treatment of neurodegenerative diseases TAKAEDA CHEMICAL IND LTD 2014-06-04 CN disclosed