Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.82 |
| ▸ | TSHR | P16473 | 5/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.79 |
| ▸ | TP53 | P04637 | 1/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL27312708 | 0.92 | ALDH1A1 (0.96) | ALDH1A1TSHRLMNAMAPK1CYP3A4 | |
| SCHEMBL27628394 | 0.92 | ALDH1A1 (0.96) | ALDH1A1TSHRLMNAMAPK1CYP3A4 | |
| Hydrogen Peroxide SCHEMBL27884113 | 0.92 | ALDH1A1 (0.96) | ALDH1A1TSHRLMNAMAPK1CYP3A4 | |
| Benzene SCHEMBL28110825 | 0.91 | ALDH1A1 (0.93) | ALDH1A1TSHRLMNAMAPK1CYP3A4 | |
| Benzene SCHEMBL28292479 | 0.91 | ALDH1A1 (0.93) | ALDH1A1TSHRLMNAMAPK1CYP3A4 | |
| Benzene SCHEMBL28168974 | 0.91 | ALDH1A1 (0.93) | ALDH1A1TSHRLMNAMAPK1CYP3A4 | |
| Benzene SCHEMBL28838429 | 0.91 | ALDH1A1 (0.93) | ALDH1A1TSHRLMNAMAPK1CYP3A4 | |
| SCHEMBL6351105 | 0.91 | ALDH1A1 (1.00) | ALDH1A1TSHRLMNAMAPK1CYP3A4 | |
| SCHEMBL111972 | 0.91 | ALDH1A1 (1.00) | ALDH1A1TSHRLMNAMAPK1CYP3A4 | |
| SCHEMBL10379553 | 0.91 | ALDH1A1 (1.00) | ALDH1A1TSHRLMNAMAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103965609-A | Modified polyphenyl thioether material containing rose ethereal oil for automobile plastic part | ANHUI YICAINI FIBER MATERIALS TECHNOLOGY CO LTD | 2014-08-06 | — | — | CN | disclosed |