Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.41 |
| ▸ | GABRE | P78334 | 2/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1433579 | 0.83 | ESR1 (0.50) | USP5CYP1A2GABRPGABRDGABRA1 | |
| SCHEMBL13383477 | 0.83 | ACHE (0.53) | ALOX5USP5CYP1A2GABRPGABRD | |
| SCHEMBL16527043 | 0.83 | ACHE (0.53) | ALOX5USP5CYP1A2GABRPGABRD | |
| SCHEMBL16527237 | 0.83 | ACHE (0.53) | ALOX5USP5CYP1A2GABRPGABRD | |
| SCHEMBL242853 | 0.82 | RIPK1 (0.52) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10042378 | 0.82 | RIPK1 (0.52) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8673121 | 0.82 | RIPK1 (0.52) | CYP1A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL25173307 | 0.81 | USP5 (0.43) | ALOX5USP5CYP1A2SMN1; SMN2GABRP | |
| SCHEMBL2692841 | 0.81 | USP5 (0.47) | ALOX5USP5CYP1A2SMN1; SMN2GABRP | |
| SCHEMBL9081205 | 0.81 | USP5 (0.47) | USP5CYP1A2SMN1; SMN2FFAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104284899-A | Tricyclic compounds and methods of use therefor | HOFFMANN LA ROCHE | 2015-01-14 | — | — | CN | disclosed |