Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | CPA3 | P15088 | 1/20 | 0.47 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.45 |
| ▸ | GABRD | O14764 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10042378 | 1.00 | RIPK1 (0.52) | RIPK1TRPA1CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL242853 | 1.00 | RIPK1 (0.52) | RIPK1TRPA1CYP1A2ALDH1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL5743278 | 0.98 | RIPK1 (0.50) | RIPK1TRPA1CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL1716157 | 0.88 | CYSLTR2 (0.50) | RIPK1TRPA1CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL8024424 | 0.86 | TBXAS1 (0.53) | RIPK1TRPA1CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL270135 | 0.86 | RIPK1 (0.50) | RIPK1TRPA1ALDH1A1TAAR1FFAR1 | |
| SCHEMBL6718333 | 0.86 | RIPK1 (0.50) | RIPK1TRPA1TAAR1FFAR1 | |
| SCHEMBL10042380 | 0.85 | HDAC1 (0.54) | — | |
| SCHEMBL10042375 | 0.85 | HDAC1 (0.54) | — | |
| SCHEMBL31462398 | 0.85 | TBXAS1 (0.55) | RIPK1ALDH1A1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843941-A | Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0763537-A2 | Non-peptidyl Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| US-5532359-A | FUNGICIDES | GENENTECH, INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0698015-A1 | PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE | GENENTECH, INC. (US) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | disclosed |