Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27970900 | 0.81 | LMNA (0.43) | LMNATRPM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27970905 | 0.79 | LMNA (0.44) | LMNATRPM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13996619 | 0.75 | LMNA (0.62) | LMNATRPM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28813152 | 0.75 | PTPRF (0.51) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL27970910 | 0.75 | TRPM5 (0.46) | LMNATRPM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27970918 | 0.73 | PTPN1 (0.60) | LMNANPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL21940886 | 0.73 | LMNA (0.56) | LMNATRPM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27970999 | 0.72 | TRPM5 (0.45) | LMNATRPM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27971031 | 0.71 | KDR (0.46) | TRPM5NPC1RAB9ASMN1; SMN2NAMPT | |
| SCHEMBL27971058 | 0.71 | TRPM5 (0.47) | LMNATRPM5NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103992310-A | Group of substituted benzoheterocycle amine derivatives and preparation method and related application thereof as IMPDH (inosine monophosphate dehydrogenase) inhibitor | INST MEDICINAL BIOTECHNOLOGY | 2014-08-20 | — | — | CN | disclosed |