Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRF | P10586 | 1/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029620 | 0.78 | CYP3A4 (0.49) | PTPN1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2542456 | 0.76 | CYP3A4 (0.61) | PTPRFPTPN2PTPN1PTPN11MAPT | |
| SCHEMBL4953680 | 0.76 | PTPRF (0.83) | PTPRFPTPN2PTPN1PTPN11MAPT | |
| SCHEMBL27971027 | 0.75 | PTPRF (0.51) | PTPRFPTPN2PTPN1PTPN11MAPT | |
| SCHEMBL27971024 | 0.75 | LMNA (0.45) | PTPN1PTPN11MAPTMEN1KMT2A | |
| SCHEMBL6699468 | 0.73 | PTPRF (0.78) | PTPRFPTPN2PTPN1PTPN11MAPT | |
| SCHEMBL27970900 | 0.73 | LMNA (0.43) | PTPN1PTPN11MAPTMEN1KMT2A | |
| SCHEMBL22783774 | 0.72 | PTPRF (0.75) | PTPRFPTPN2PTPN1PTPN11MAPT | |
| SCHEMBL10938044 | 0.72 | PTPRF (0.60) | PTPRFPTPN2PTPN1PTPN11MAPT | |
| SCHEMBL531299 | 0.72 | PTPRF (0.60) | PTPRFPTPN2PTPN1PTPN11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103992310-A | Group of substituted benzoheterocycle amine derivatives and preparation method and related application thereof as IMPDH (inosine monophosphate dehydrogenase) inhibitor | INST MEDICINAL BIOTECHNOLOGY | 2014-08-20 | — | — | CN | disclosed |