Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27972580 | 0.89 | BCHE (0.49) | MAPTMAPK14GAARAB9ANPC1 | |
| SCHEMBL28260015 | 0.86 | HCAR2 (0.41) | MAPTNAMPTMAPK14LMNASMN1; SMN2 | |
| SCHEMBL27972588 | 0.85 | HDAC3 (0.38) | MAPTHTTNAMPTMAPK14RAB9A | |
| SCHEMBL28259972 | 0.82 | NPC1 (0.47) | MAPTHTTGAARAB9ALMNA | |
| SCHEMBL28866664 | 0.81 | PTPN1 (0.52) | MAPTHTTMAPK14GAARAB9A | |
| SCHEMBL27972283 | 0.80 | MEN1 (0.41) | MAPTMAPK14RAB9ALMNANPC1 | |
| SCHEMBL27972334 | 0.79 | PDE3B (0.52) | NAMPTROCK2RORC | |
| SCHEMBL27972318 | 0.79 | PTPN1 (0.48) | MAPTROCK2LMNANPC1SMN1; SMN2 | |
| SCHEMBL27972313 | 0.79 | KCNJ5 (0.50) | MAPTROCK2LMNASMN1; SMN2MEN1 | |
| SCHEMBL28259952 | 0.78 | PTPN1 (0.52) | MAPK14SMN1; SMN2HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483423-A | P2X4 receptor antagonist | NIPPON CHEMIPHAR CO | 2019-11-22 | — | — | CN | disclosed |
| CN-108863959-A | P2X4 RECEPTOR ANTAGONIST | 日本化学药品株式会社 | 2018-11-23 | — | — | CN | disclosed |
| CN-104066724-A | P2X4 receptor antagonists | NIPPON CHEMIPHAR CO | 2014-09-24 | — | — | CN | disclosed |