Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28866664 | 0.95 | PTPN1 (0.52) | PTPN1MAPK14SMN1; SMN2KDM4EDEGS1 | |
| SCHEMBL27972606 | 0.87 | KDM4E (0.51) | SMN1; SMN2KDM4EPOLBSTAT3KCNK3 | |
| SCHEMBL27972353 | 0.87 | NAMPT (0.51) | SMN1; SMN2KDM4EHDAC6KCNK3 | |
| SCHEMBL28259968 | 0.84 | NPC1 (0.48) | SMN1; SMN2KDM4EHDAC8HDAC6DEGS1 | |
| SCHEMBL28426457 | 0.82 | CHRNB2 (0.43) | SMN1; SMN2POLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL27972271 | 0.82 | RAB9A (0.53) | SMN1; SMN2KDM4EKCNK3 | |
| SCHEMBL27972549 | 0.81 | SMO (0.53) | SMN1; SMN2 | |
| SCHEMBL28279915 | 0.81 | MEN1 (0.49) | POLBCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL27972568 | 0.81 | MEN1 (0.53) | PTPN1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL27972571 | 0.80 | EPHX2 (0.48) | HDAC2HDAC8HDAC6CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483423-A | P2X4 receptor antagonist | NIPPON CHEMIPHAR CO | 2019-11-22 | — | — | CN | disclosed |
| CN-108863959-A | P2X4 RECEPTOR ANTAGONIST | 日本化学药品株式会社 | 2018-11-23 | — | — | CN | disclosed |