Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27593722 | 0.92 | MAPT (0.51) | CYP4F2CYP4A11MAPTKDM4ETSHR | |
| SCHEMBL26264596 | 0.86 | LMNA (0.50) | MAPTKDM4ETSHRCYP4Z1SMN1; SMN2 | |
| SCHEMBL4643463 | 0.85 | CYP4F2 (0.52) | CYP4F2CYP4A11MAPTKDM4ETSHR | |
| SCHEMBL8790409 | 0.82 | TSHR (0.55) | MAPTKDM4ETSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL397878 | 0.82 | CYP4F2 (0.47) | CYP4F2CYP4A11MAPTKDM4EMITF | |
| SCHEMBL27640326 | 0.80 | LMNA (0.49) | MAPTKDM4ETSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL4644934 | 0.80 | CYP4F2 (0.50) | CYP4F2CYP4A11MAPTKDM4EMITF | |
| SCHEMBL13991528 | 0.80 | CYP4F2 (0.64) | CYP4F2CYP4A11MAPTKDM4ETSHR | |
| SCHEMBL4644322 | 0.79 | CYP4F2 (0.52) | CYP4F2CYP4A11MAPTKDM4EMITF | |
| SCHEMBL4642309 | 0.79 | CYP4F2 (0.46) | CYP4F2CYP4A11MAPTKDM4EMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103958472-A | Aryl-or N-heteroaryl-substituted methanesulfonamide derivatives as vanilloid receptor ligands | GRUENENTHAL GMBH | 2014-07-30 | — | — | CN | disclosed |