Fluorene

Fluorene

SCHEMBL27984071

CCCCCCCCCC(=O)O.c1ccc2c(c1)Cc1ccccc1-2

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 7/20 0.57
PPARG P37231 7/20 0.57
PPARD Q03181 7/20 0.57
PPARA Q07869 7/20 0.57
HDAC11 Q96DB2 5/20 0.57
TSHR P16473 4/20 0.57
PTPN1 P18031 3/20 0.57
ALDH1A1 P00352 2/20 0.57
TLR2 O60603 2/20 0.57
TDP1 Q9NUW8 2/20 0.57
FABP4 P15090 2/20 0.57
KMT2A Q03164 2/20 0.57
SLC22A6 Q4U2R8 1/20 0.57
SLC22A8 Q8TCC7 1/20 0.57
MEN1 O00255 1/20 0.57
ESR1 P03372 1/20 0.57
ALOX15 P16050 1/20 0.57
PDE4A P27815 1/20 0.57
PDE3A Q14432 1/20 0.57
HSD17B10 Q99714 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Undecanoate SCHEMBL28476457 1.00 GPR84 (0.57) GPR84PPARGPPARDPPARAHDAC11
Undecanoate SCHEMBL28151741 1.00 GPR84 (0.57) GPR84PPARGPPARDPPARAHDAC11
Fluorene SCHEMBL17443012 0.98 AKR1B1 (0.55) GPR84PPARGPPARDPPARAHDAC11
Fluorene SCHEMBL27386948 0.86 NPC1 (0.56) TSHRALDH1A1ALOX15CES2CES1
Fluorene SCHEMBL27692624 0.86 NPC1 (0.48) GPR84PPARGPPARDPPARAHDAC11
Fluorene SCHEMBL28775248 0.86 SRD5A2 (0.55) HDAC11TSHRALDH1A1SLC22A6ALOX15
Fluorene SCHEMBL27803639 0.86 ALDH1A1 (0.50) TSHRPTPN1ALDH1A1HSD17B10MAPT
Fluorene SCHEMBL28135016 0.86 ALDH1A1 (0.50) TSHRPTPN1ALDH1A1HSD17B10MAPT
Fluorene SCHEMBL25291666 0.84 MAOA (0.50) TSHRALDH1A1HSD17B10MAPTCES1
Fluorene SCHEMBL28311286 0.82 SRD5A2 (0.55) TSHRALDH1A1ALOX15HSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104039789-A Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators MERCK PATENT GMBH 2014-09-10 CN disclosed