Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 18/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27984611 | 1.00 | PI4KB (0.41) | PI4KBCXCR3GRM1KCNH2 | |
| SCHEMBL27984954 | 0.88 | GRM1 (0.39) | CXCR3GRM1KCNH2 | |
| SCHEMBL15157120 | 0.85 | GPR119 (0.46) | PI4KBCXCR3 | |
| SCHEMBL15157124 | 0.85 | GPR119 (0.46) | PI4KBCXCR3 | |
| SCHEMBL28814375 | 0.85 | TRPC6 (0.35) | PI4KBCXCR3KCNH2 | |
| SCHEMBL28814373 | 0.85 | TRPC6 (0.35) | PI4KBCXCR3KCNH2 | |
| SCHEMBL27984619 | 0.82 | CXCR3 (0.40) | PI4KBCXCR3KCNH2 | |
| SCHEMBL27984617 | 0.82 | CXCR3 (0.40) | PI4KBCXCR3KCNH2 | |
| SCHEMBL15156579 | 0.78 | HDAC1 (0.37) | — | |
| SCHEMBL15156582 | 0.78 | HDAC1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104093715-A | 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives | ACTELION PHARMACEUTICALS LTD | 2014-10-08 | — | — | CN | disclosed |