Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PIR | O00625 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17996448 | 0.88 | LMNA (0.80) | LMNANPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17996450 | 0.86 | LMNA (1.00) | LMNANPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17996449 | 0.85 | LMNA (0.76) | LMNANPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3149489 | 0.84 | LMNA (0.74) | LMNANPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17137602 | 0.80 | LMNA (0.53) | LMNANPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17137286 | 0.80 | LMNA (0.53) | LMNANPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL9633894 | 0.79 | KMT2A (0.73) | LMNANPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17015171 | 0.78 | KMT2A (1.00) | LMNANPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17996453 | 0.78 | KMT2A (1.00) | LMNANPSR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL11132471 | 0.74 | ALDH1A1 (1.00) | LMNANPSR1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104119246-A | Cyclopropane derivatives, and preparation method and application thereof | SHANGHAI INST ORGANIC CHEM | 2014-10-29 | — | — | CN | disclosed |