Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 4/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 4/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27987403 | 1.00 | AXL (0.43) | AXLTYRO3MERTKKCNH2SCN5A | |
| SCHEMBL28814769 | 0.81 | PRKCI (0.47) | MAP4K1IRAK4 | |
| SCHEMBL28814767 | 0.81 | PRKCI (0.47) | MAP4K1IRAK4 | |
| SCHEMBL27987771 | 0.80 | PRKCI (0.47) | CLK2CLK3DYRK1AMAP4K1BRD4 | |
| SCHEMBL13354595 | 0.79 | HRH3 (0.42) | CLK2CLK3DYRK1AMAP4K1BRD4 | |
| SCHEMBL15219256 | 0.79 | CLK2 (0.44) | CLK2CLK3DYRK1AMAP4K1BRD4 | |
| SCHEMBL4131760 | 0.77 | ITK (0.50) | AXLTYRO3MERTKKCNH2ITK | |
| SCHEMBL11916057 | 0.76 | HRH4 (0.45) | CLK2CLK3DYRK1AMAP4K1BRD4 | |
| SCHEMBL14955891 | 0.76 | SYK (0.52) | AXLTYRO3MERTKKCNH2CLK2 | |
| SCHEMBL14955888 | 0.76 | SYK (0.52) | AXLTYRO3MERTKKCNH2CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104066431-B | Pyrazine kinase inhibitors | 波托拉医药品公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-104066431-A | Pyrazine kinase inhibitors | PORTOLA PHARM INC | 2014-09-24 | — | — | CN | disclosed |