Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 6/20 | 0.47 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 4/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27987404 | 0.80 | AXL (0.43) | BRD4ATAD2IRAK4MAP4K1CLK2 | |
| SCHEMBL27987403 | 0.80 | AXL (0.43) | BRD4ATAD2IRAK4MAP4K1CLK2 | |
| SCHEMBL27322594 | 0.78 | BRD4 (0.56) | PRKCIBRD4ATAD2PRKCZMEN1 | |
| SCHEMBL28135186 | 0.78 | CCNT1 (0.46) | PRKCIIRAK4PIM1PIM2 | |
| SCHEMBL28135187 | 0.78 | CCNT1 (0.46) | PRKCIIRAK4PIM1PIM2 | |
| SCHEMBL15219256 | 0.77 | CLK2 (0.44) | PRKCIBRD4ATAD2IRAK4MAP4K1 | |
| SCHEMBL13354595 | 0.77 | HRH3 (0.42) | PRKCIBRD4ATAD2IRAK4MAP4K1 | |
| SCHEMBL28814767 | 0.77 | PRKCI (0.47) | PRKCIIRAK4MAP4K1PRKCZCYP1A2 | |
| SCHEMBL28814769 | 0.77 | PRKCI (0.47) | PRKCIIRAK4MAP4K1PRKCZCYP1A2 | |
| SCHEMBL28134516 | 0.74 | PRKCI (0.47) | PRKCIPRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104066431-B | Pyrazine kinase inhibitors | 波托拉医药品公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-104066431-A | Pyrazine kinase inhibitors | PORTOLA PHARM INC | 2014-09-24 | — | — | CN | disclosed |