Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.47 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | NRAS | P01111 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28814769 | 1.00 | PRKCI (0.47) | PRKCIIDH2PRKCZADRA2AADRA2B | |
| SCHEMBL7098800 | 0.82 | CHRNB2 (0.48) | PRKCIIDH2PRKCZADRA2AADRA2B | |
| SCHEMBL23013465 | 0.82 | CHRNB2 (0.48) | PRKCIIDH2PRKCZADRA2AADRA2B | |
| SCHEMBL23012617 | 0.82 | CHRNB2 (0.48) | PRKCIIDH2PRKCZADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL23012717 | 0.81 | CHRNB2 (0.47) | PRKCIIDH2PRKCZADRA2AADRA2B | |
| SCHEMBL27987404 | 0.81 | AXL (0.43) | IRAK4MAP4K1 | |
| SCHEMBL27987403 | 0.81 | AXL (0.43) | IRAK4MAP4K1 | |
| SCHEMBL14955637 | 0.78 | SYK (0.49) | PRKCIROCK1IRAK4LCKRET | |
| SCHEMBL14955641 | 0.78 | SYK (0.49) | PRKCIROCK1IRAK4LCKRET | |
| SCHEMBL27987771 | 0.77 | PRKCI (0.47) | PRKCIPRKCZIRAK4MAP4K1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104066431-B | Pyrazine kinase inhibitors | 波托拉医药品公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-104066431-A | Pyrazine kinase inhibitors | PORTOLA PHARM INC | 2014-09-24 | — | — | CN | disclosed |