Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.40 |
| ▸ | BPTF | Q12830 | 2/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | NRAS | P01111 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.37 |
| ▸ | PRKCI | P41743 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15219256 | 0.84 | CLK2 (0.44) | HRH3HRH4HRH2CLK2CLK3 | |
| SCHEMBL11916057 | 0.81 | HRH4 (0.45) | HRH3HRH4HRH2CLK2CLK3 | |
| SCHEMBL27987404 | 0.79 | AXL (0.43) | CLK2CLK3DYRK1AIRAK4MAP4K1 | |
| SCHEMBL27987403 | 0.79 | AXL (0.43) | CLK2CLK3DYRK1AIRAK4MAP4K1 | |
| SCHEMBL27987771 | 0.77 | PRKCI (0.47) | CLK2CLK3DYRK1AIRAK4MAP4K1 | |
| SCHEMBL16303847 | 0.76 | PRKCZ (0.46) | IRAK4BPTFFLT3IRAK1BRD4 | |
| SCHEMBL28814769 | 0.76 | PRKCI (0.47) | IRAK4MAP4K1NRASFLT3IRAK1 | |
| SCHEMBL28814767 | 0.76 | PRKCI (0.47) | IRAK4MAP4K1NRASFLT3IRAK1 | |
| SCHEMBL13359844 | 0.74 | PRKCI (0.48) | HRH3HRH4HRH2IRAK4MAP4K1 | |
| SCHEMBL13326537 | 0.74 | PRKCI (0.48) | HRH3HRH4HRH2IRAK4MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056311-A1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2009143389-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |