Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3316532 | 0.90 | HTR2C (0.66) | HTR2CDRD2ADRA1AHTR2AHTR2B | |
| SCHEMBL29042969 | 0.86 | HTR2C (0.60) | HTR2CDRD2TACR1ADRA1AHTR2A | |
| SCHEMBL29866158 | 0.81 | DRD2 (0.52) | HTR2CDRD2 | |
| SCHEMBL30997824 | 0.81 | HTR2C (0.77) | HTR2CDRD2ADRA1AHTR2AHTR2B | |
| SCHEMBL1515134 | 0.81 | HTR2C (0.77) | HTR2CDRD2ADRA1AHTR2AHTR2B | |
| SCHEMBL14894409 | 0.80 | DYRK1A (0.45) | HTR2C | |
| SCHEMBL31618407 | 0.80 | DRD2 (0.51) | HTR2CDRD2 | |
| SCHEMBL14893752 | 0.80 | DRD2 (0.45) | DRD2ADRA1A | |
| SCHEMBL27759433 | 0.78 | DRD2 (0.44) | DRD2ADRA1A | |
| SCHEMBL20117303 | 0.78 | HTR2C (0.54) | HTR2CDRD2HTR2AHTR2BCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4274828-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie Global Enterprises Ltd. (BM) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022150174-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie Global Enterprises Ltd. (BM) | 2022-07-14 | — | — | WO | disclosed |
| CN-104292190-A | Synthesis method for beta-brominated tetrahydrofuran compound | HARBIN INST OF TECHNOLOGY | 2015-01-21 | — | — | CN | disclosed |