Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSH | P09668 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370831 | 0.82 | CYP1A2 (0.52) | MMP8LIPECTSSCTSLCTSB | |
| SCHEMBL2680002 | 0.78 | CPA3 (0.55) | MMP8MEN1KMT2AMAPK1MAPT | |
| SCHEMBL28006830 | 0.76 | MMP8 (0.48) | MMP8LIPECTSSCTSLCTSB | |
| SCHEMBL27923292 | 0.75 | MMP8 (0.49) | MMP8LIPECTSSLMNACTSL | |
| SCHEMBL27563063 | 0.73 | MMP8 (0.50) | MMP8LIPECTSSCTSLCTSB | |
| SCHEMBL27563062 | 0.73 | MMP8 (0.50) | MMP8LIPECTSSCTSLCTSB | |
| SCHEMBL7287463 | 0.72 | MMP8 (0.51) | MMP8LIPECTSSCTSLCTSB | |
| SCHEMBL7288147 | 0.72 | CPA1 (0.53) | MMP8LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL9110135 | 0.71 | CYP1A2 (0.53) | — | |
| SCHEMBL9108793 | 0.71 | CYP1A2 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103582630-B | Enkephalinase inhibitor | 施万生物制药研发IP有限责任公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103261168-B | Enkephalinase inhibitor | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-05 | — | — | CN | disclosed |
| CN-104470521-A | Neprilysin inhibitors | THERAVANCE INC | 2015-03-25 | — | — | CN | disclosed |
| CN-104350042-A | Neprilysin inhibitors | THERAVANCE BIOPHARMA R & D IP LLC | 2015-02-11 | — | — | CN | disclosed |
| CN-104350052-A | Nitric oxide donor neprilysin inhibitors | THERAVANCE BIOPHARMA R & D IP LLC | 2015-02-11 | — | — | CN | disclosed |