Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680002 | 0.85 | CPA3 (0.55) | MMP8MEN1ALDH1A1KMT2ACPA3 | |
| SCHEMBL7370831 | 0.80 | CYP1A2 (0.52) | MMP8CDK5CDK5R1LIPEMEN1 | |
| SCHEMBL7288147 | 0.78 | CPA1 (0.53) | MMP8MEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7287463 | 0.78 | MMP8 (0.51) | MMP8CDK5CDK5R1LIPEMEN1 | |
| SCHEMBL27563062 | 0.77 | MMP8 (0.50) | MMP8CDK5CDK5R1LIPEMEN1 | |
| SCHEMBL27563063 | 0.77 | MMP8 (0.50) | MMP8CDK5CDK5R1LIPEMEN1 | |
| SCHEMBL27997607 | 0.76 | MMP8 (0.42) | MMP8LIPEMEN1ALDH1A1KMT2A | |
| SCHEMBL27923292 | 0.76 | MMP8 (0.49) | MMP8CDK5CDK5R1LIPEMEN1 | |
| SCHEMBL27773554 | 0.76 | MMP8 (0.49) | MMP8CDK5CDK5R1LIPEMEN1 | |
| SCHEMBL7536026 | 0.75 | MMP8 (0.45) | MMP8CDK5CDK5R1LIPEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105992763-A | Neprilysin inhibitors | 施万生物制药研发IP有限责任公司 | 2016-10-05 | — | — | CN | disclosed |
| CN-105960398-A | 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors | 施万生物制药研发IP有限责任公司 | 2016-09-21 | — | — | CN | disclosed |
| CN-105026374-A | Neprilysin inhibitors | THERAVANCE INC | 2015-11-04 | — | — | CN | disclosed |
| CN-104520277-A | Enkephalinase inhibitors | THERAVANCE INC | 2015-04-15 | — | — | CN | disclosed |