Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28086157 | 0.98 | LMNA (0.51) | GAALMNAKMT2AALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL28314858 | 0.97 | LMNA (0.54) | GAALMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL28049253 | 0.95 | LMNA (0.47) | GAALMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL28822692 | 0.86 | GAA (0.40) | GAALMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL27995211 | 0.85 | ATM (0.41) | GAALMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL28816744 | 0.84 | MEN1 (0.51) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27968133 | 0.84 | ATM (0.38) | GAALMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL9392253 | 0.84 | GAA (0.53) | GAALMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL10254763 | 0.84 | KMT2A (0.54) | GAALMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL28299375 | 0.83 | KCNA3 (0.43) | GAALMNAALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110072857-A | 1, 3-disubstituted cyclobutanone or azetidine derivatives as hematopoietic prostaglandin D synthase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2019-07-30 | — | — | CN | claimed |
| CN-105473554-B | Condensed piperidine amide as ion channel modulators | 沃泰克斯药物股份有限公司 | 2019-08-13 | — | — | CN | disclosed |
| CN-110072857-A | 1, 3-disubstituted cyclobutanone or azetidine derivatives as hematopoietic prostaglandin D synthase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-110036004-A | Inhibitors of cyclin dependent kinase 7(CDK7) | 希洛斯医药品股份有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-109879859-A | COT regulator and its application method | 吉利德科学公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-107922390-B | COT modulators and methods of use thereof | 吉利德科学公司 | 2019-05-10 | — | — | CN | disclosed |
| CN-109415355-A | Benzdioxan derivative and its medicinal usage | 奥赖恩公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109053742-A | New tricyclic compound | ABBVIE 公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-103958506-B | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH | 诺华股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-105555778-A | Cyclic amine derivative and pharmaceutical use thereof | TORAY INDUSTRIES | 2016-05-04 | — | — | CN | disclosed |
| CN-105473554-A | Fused piperidine amides as modulators of ion channels | VERTEX PHARMA | 2016-04-06 | — | — | CN | disclosed |
| CN-102918042-B | 8-methyl-1-phenyl-imidazo [1,5-a ] pyrazine compounds | MERCK SHARP & DOHME B.V. (NL) | 2016-03-09 | — | — | CN | disclosed |
| CN-104955824-A | Aminopyrimidine compounds as inhibitors of t790m containing egfr mutants | GENENTECH INC | 2015-09-30 | — | — | CN | disclosed |
| CN-102827067-B | Beta-lactamase inhibitor | SCHERING CORPORATION (US) | 2015-09-23 | — | — | CN | disclosed |
| CN-104812748-A | Dihydropyrazole GPR40 modulators | BRISTOL MYERS SQUIBB CO | 2015-07-29 | — | — | CN | disclosed |
| CN-101679266-B | PIM kinase inhibitors and methods of their use | NOVARTIS AG | 2015-05-06 | — | — | CN | disclosed |
| CN-104379560-A | Benzamide derivative | CHUGAI PHARMACEUTICAL CO LTD | 2015-02-25 | — | — | CN | disclosed |