Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28314858 | 0.98 | LMNA (0.54) | LMNAGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL27999947 | 0.98 | GAA (0.53) | LMNAGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL28049253 | 0.97 | LMNA (0.47) | LMNAGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL27995211 | 0.87 | ATM (0.41) | LMNAGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL27968133 | 0.86 | ATM (0.38) | LMNAGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL28816744 | 0.86 | MEN1 (0.51) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28822692 | 0.85 | GAA (0.40) | LMNAGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL28299375 | 0.84 | KCNA3 (0.43) | LMNAGAAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28013981 | 0.84 | LMNA (0.40) | LMNAGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL4961610 | 0.83 | LMNA (0.51) | LMNAGAAKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074848-B | Pyrrolidine compounds | GlaxoSmithKline Intellectual Property Development Ltd. (GB) | 2019-11-01 | — | — | CN | disclosed |
| CN-110234638-A | Heteroaryl phenoxy benzamide KAPPA opiates ligand | 辉瑞大药厂 | 2019-09-13 | — | — | CN | disclosed |
| CN-105431420-B | Diheteroaryl compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2019-08-13 | — | — | CN | disclosed |
| CN-107531714-B | Imidazopyrazines ketone as PDE1 inhibitor | H.隆德贝克有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-110003178-A | Two heteroaryl compounds and application thereof | 豪夫迈·罗氏有限公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-107074849-A | Novel compounds | 葛兰素史密斯克莱知识产权发展有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-103717589-B | For treating or prevent the compound of respiratory syncytial virus disease | 弗·哈夫曼-拉罗切有限公司 | 2016-08-17 | — | — | CN | disclosed |