Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27817087 | 0.81 | P2RX7 (0.30) | — | |
| SCHEMBL28003061 | 0.80 | CYP2A6 (0.42) | LMNAMAPT | |
| SCHEMBL28003002 | 0.79 | CYP1A2 (0.30) | — | |
| SCHEMBL28831583 | 0.79 | NISCH (0.32) | — | |
| SCHEMBL28002712 | 0.70 | TAAR1 (0.35) | NOTUM | |
| SCHEMBL28003039 | 0.70 | KDM4E (0.36) | NOTUM | |
| SCHEMBL14772862 | 0.59 | MAPT (0.37) | LMNAMAPTNOTUM | |
| SCHEMBL9728 | 0.57 | MAPT (1.00) | LMNAMAPTNOTUMHDAC8 | |
| SCHEMBL22673876 | 0.56 | LMNA (0.37) | LMNAMAPTNOTUM | |
| SCHEMBL20851921 | 0.56 | MAPT (0.37) | LMNAMAPTNOTUMHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104411709-B | Can be used as imidazo [2, the 1] thiazole-3-ketone derivatives of the diagnostic agent of Alzheimer | 霍夫曼-拉罗奇有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-104411709-A | Imidazo [2,1]thiazol-3-one derivatives useful as diagnostic agents for alzheimer's disease | HOFFMANN LA ROCHE | 2015-03-11 | — | — | CN | disclosed |