Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.61 |
| ▸ | CA2 | P00918 | 6/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11674731 | 0.90 | MEN1 (0.50) | CA1CA2MAPK1ALDH1A1MAPT | |
| SCHEMBL23401342 | 0.85 | TDP1 (0.51) | CA1CA2MAPK1ALDH1A1MAPT | |
| SCHEMBL23400590 | 0.85 | TDP1 (0.51) | CA1CA2MAPK1ALDH1A1MAPT | |
| SCHEMBL30639609 | 0.84 | KDM4E (0.50) | CA1CA2MAPK1MAPTMEN1 | |
| SCHEMBL31617351 | 0.78 | CA1 (0.43) | CA1CA2MAPK1ALDH1A1MAPT | |
| SCHEMBL23400489 | 0.78 | SMN1; SMN2 (0.40) | CA1CA2ALDH1A1MAPTMEN1 | |
| SCHEMBL23399153 | 0.77 | CA1 (0.43) | CA1CA2MAPK1ALDH1A1MAPT | |
| SCHEMBL23400259 | 0.76 | KMT2A (0.42) | CA1CA2MAPK1ALDH1A1MAPT | |
| SCHEMBL11675583 | 0.75 | CA1 (0.54) | CA1CA2MAPK1ALDH1A1MAPT | |
| SCHEMBL8214143 | 0.75 | ALDH1A1 (0.54) | CA1CA2MAPK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117045647-A | Application of 4-hydroxypyrazole compounds, derivatives and salts thereof in preparation of iron death inhibiting drugs | 浙江大学 | 2023-11-14 | — | — | CN | claimed |
| CN-104356066-B | Preparation method of multi-substituted 4-hydroxypyrazole derivative | 浙江大学 | 2017-01-18 | — | — | CN | claimed |
| CN-104356066-A | Preparation method of multi-substituted 4-hydroxypyrazole derivative | UNIV ZHEJIANG | 2015-02-18 | — | — | CN | claimed |
| CN-117045647-A | Application of 4-hydroxypyrazole compounds, derivatives and salts thereof in preparation of iron death inhibiting drugs | 浙江大学 | 2023-11-14 | — | — | CN | disclosed |
| CN-104356066-B | Preparation method of multi-substituted 4-hydroxypyrazole derivative | 浙江大学 | 2017-01-18 | — | — | CN | disclosed |
| CN-104356066-A | Preparation method of multi-substituted 4-hydroxypyrazole derivative | UNIV ZHEJIANG | 2015-02-18 | — | — | CN | disclosed |