Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.46 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.34 |
| ▸ | GLRB | P48167 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28452283 | 0.77 | HTR2C (0.52) | HTR2CHTR2BADAM10MMP2PDE10A | |
| SCHEMBL25985252 | 0.77 | HTR2C (0.41) | KDM1AHTR2CHTR2BALDH1A1PDE10A | |
| SCHEMBL434606 | 0.77 | KDM1A (0.52) | KDM1AKDM1BHTR2CHTR2BKDM4E | |
| SCHEMBL18517725 | 0.76 | KDM1A (0.35) | KDM1AKDM1BHTR2CHTR2BKDM4E | |
| SCHEMBL13788618 | 0.75 | PDE2A (0.38) | HTR2CGAAHTR1ASLC6A2SLC6A4 | |
| SCHEMBL2455760 | 0.75 | HCAR2 (0.41) | HCAR2PDE10A | |
| SCHEMBL20021198 | 0.75 | HTR2C (0.41) | KDM1AKDM1BHTR2CHTR2BKDM4E | |
| SCHEMBL23228754 | 0.74 | HTR2C (0.53) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1794059 | 0.73 | ALDH1A1 (0.34) | ALDH1A1PDE10A | |
| SCHEMBL29866154 | 0.73 | OPRL1 (0.34) | ALDH1A1PDE10ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108383858-A | Treat the derivative of the imidazo thiadiazoles and Imidazopyrazines of platelet aggregation | 百时美施贵宝公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-104583218-B | Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4(PAR4) inhibitors for the treatment of platelet aggregation | 百时美施贵宝公司 | 2018-04-24 | — | — | CN | disclosed |
| CN-104583218-A | Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4(PAR4) inhibitors for the treatment of platelet aggregation | BRISTOL MYERS SQUIBB CO | 2015-04-29 | — | — | CN | disclosed |