Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367851 | 0.82 | SMN1; SMN2 (0.36) | NPC1HTTL3MBTL1SMN1; SMN2PPP1CA | |
| SCHEMBL28003700 | 0.79 | SMN1; SMN2 (0.42) | NPC1HTTL3MBTL1SMN1; SMN2PPP1CA | |
| SCHEMBL28047795 | 0.76 | L3MBTL1 (0.43) | NPC1L3MBTL1RAB9AMPOTAAR1 | |
| SCHEMBL27988286 | 0.73 | MET (0.42) | NPC1HTTL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30800189 | 0.73 | NPC1 (0.37) | NPC1HTTL3MBTL1SMN1; SMN2PPP1CA | |
| SCHEMBL21751301 | 0.73 | NPC1 (0.37) | NPC1HTTL3MBTL1SMN1; SMN2PPP1CA | |
| SCHEMBL1163489 | 0.69 | MET (0.41) | NPC1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL28206392 | 0.69 | ADORA2A (0.42) | NPC1HTTL3MBTL1SMN1; SMN2PPP1CA | |
| SCHEMBL29520054 | 0.68 | CHRNA7 (0.44) | ALDH1A1MPOPKM | |
| SCHEMBL5205493 | 0.67 | TAAR1 (0.46) | NPC1HTTSMN1; SMN2ALDH1A1MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104583199-A | 2-aminopyrazine derivatives as CSF-1R kinase inhibitors | CHROMA THERAPEUTICS LTD | 2015-04-29 | — | — | CN | disclosed |