Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15537375 | 0.82 | CDC7 (0.49) | SMN1; SMN2KDM4EPOLBNPC1HPGD | |
| SCHEMBL27664851 | 0.79 | ALDH1A1 (0.48) | SMN1; SMN2PTGDR2KDM4EPOLBHPGD | |
| SCHEMBL22588269 | 0.75 | ALDH1A1 (0.47) | HDAC1HDAC6HDAC8 | |
| SCHEMBL15488079 | 0.73 | HCAR2 (0.49) | SMN1; SMN2HCAR2PTGDR2P2RX3 | |
| SCHEMBL693543 | 0.71 | CDC7 (0.43) | SMN1; SMN2PTGDR2KDM4EPOLBNPC1 | |
| SCHEMBL19207619 | 0.71 | TSHR (0.56) | HDAC6SMN1; SMN2KDM4EPOLBNPC1 | |
| SCHEMBL19224495 | 0.68 | LMNA (0.56) | SMN1; SMN2KDM4EPOLBNPC1RAB9A | |
| SCHEMBL9555418 | 0.68 | PTGDR2 (0.60) | PTGDR2KDM4EPOLBHPGD | |
| SCHEMBL3585289 | 0.68 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4ENPC1HPGDRAB9A | |
| SCHEMBL5329779 | 0.68 | SMN1; SMN2 (0.47) | HDAC1HDAC6HDAC8SMN1; SMN2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104603118-B | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators of the orphan nuclear receptor ROR γ | 菲尼克斯药品股份公司 | 2017-10-03 | — | — | CN | disclosed |
| CN-107007597-A | It is used as the thiazole of orphan nuclear receptor ROR γ instrumentalities through formamide or sulfonamide substitutions and the pharmaceutical applications of related derivatives | 菲尼克斯药品股份公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-104603118-A | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators of the orphan nuclear receptor ROR γ | PHENEX PHARMACEUTICALS AG | 2015-05-06 | — | — | CN | disclosed |