Quinoline

Quinoline

SCHEMBL28006159

CCc1nccn1CC.c1ccc2ncccc2c1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
TSHR P16473 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
NFKB1 P19838 1/20 0.41
CYP2C19 P33261 1/20 0.41
ABCB11 O95342 1/20 0.41
ADRA2B P18089 1/20 0.41
KMT2A Q03164 3/20 0.41
MEN1 O00255 2/20 0.40
RAB9A P51151 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ALPG P10696 2/20 0.37
PLAA Q9Y263 1/20 0.37
ALPL P05186 1/20 0.36
HRH3 Q9Y5N1 1/20 0.36
KCNH2 Q12809 1/20 0.36
POLB P06746 1/20 0.36
PABPC1 P11940 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoline SCHEMBL28176038 0.85 ALDH1A1 (0.45) ALDH1A1TSHRCYP1A2CYP3A4CYP2D6
Quinoline SCHEMBL27618986 0.83 ALDH1A1 (0.53) ALDH1A1TSHRKMT2AMEN1RAB9A
Quinoline SCHEMBL27759111 0.83 ALDH1A1 (0.53) ALDH1A1TSHRCYP1A2CYP3A4CYP2C19
SCHEMBL464450 0.80
Quinoline SCHEMBL27735524 0.79 ALDH1A1 (0.49) ALDH1A1TSHRCYP1A2CYP3A4CYP2C19
SCHEMBL28104483 0.78 ALPG (0.44) ALDH1A1TSHRCYP1A2CYP3A4CYP2D6
Bromide SCHEMBL28236460 0.78 ALPG (0.44) ALDH1A1TSHRCYP1A2CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL20262982 0.78 ALPG (0.46) ALDH1A1TSHRCYP1A2CYP3A4CYP2D6
Quinoline SCHEMBL2535469 0.76 ALDH1A1 (0.81) ALDH1A1TSHRCYP1A2CYP3A4CYP2D6
Quinoline SCHEMBL4599170 0.74 ALDH1A1 (0.77) ALDH1A1TSHRCYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104498163-A Water-soluble total-synthesis metal working fluid and application thereof UNIV TSINGHUA 2015-04-08 CN claimed
CN-110476265-A Charge-transporting varnish NISSAN CHEMICAL CORP 2019-11-19 CN disclosed
CN-107709401-A Solidification compound and formed body 株式会社大赛璐 2018-02-16 CN disclosed
CN-107709403-A Curable composition and cured product using same 三亚普罗股份有限公司 2018-02-16 CN disclosed
CN-107658494-A Nonaqueous electrolyte solution and nonaqueous electrolyte secondary battery 三菱化学株式会社 2018-02-02 CN disclosed
CN-104498163-B Water-soluble total synthesis metal processing liquid and its application 清华大学 2017-06-06 CN disclosed
CN-104498163-A Water-soluble total-synthesis metal working fluid and application thereof UNIV TSINGHUA 2015-04-08 CN disclosed