Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17225381 | 0.80 | MAPT (0.50) | MAPTSMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL30241953 | 0.72 | MEN1 (0.49) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL27252381 | 0.72 | MEN1 (0.49) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL29986175 | 0.71 | ALOX15 (0.39) | SMN1; SMN2ALDH1A1TDP1L3MBTL1KDM4E | |
| SCHEMBL31554020 | 0.71 | ALOX15 (0.39) | SMN1; SMN2ALDH1A1TDP1L3MBTL1KDM4E | |
| SCHEMBL11631291 | 0.70 | ALDH1A1 (0.63) | MAPTSMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL20928644 | 0.69 | ALOX15 (0.38) | ALDH1A1TDP1L3MBTL1KDM4EALOX15 | |
| SCHEMBL31036608 | 0.69 | LMNA (0.39) | SMN1; SMN2ALDH1A1TDP1KDM4EALOX15 | |
| SCHEMBL3357653 | 0.69 | ALOX15 (0.42) | MAPTALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL14510449 | 0.69 | KMT2A (0.51) | MAPTSMN1; SMN2HTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104470363-A | 1,2, 4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARM INC | 2015-03-25 | — | — | CN | disclosed |