Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 12/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25381150 | 0.87 | L3MBTL1 (0.42) | KLKB1L3MBTL1ALDH1A1MAPTPKM | |
| SCHEMBL28818252 | 0.79 | KLKB1 (0.49) | KLKB1L3MBTL1ALDH1A1MAPTPOLB | |
| SCHEMBL28008768 | 0.79 | MAPT (0.48) | KLKB1L3MBTL1ALDH1A1MAPTPOLB | |
| SCHEMBL28008774 | 0.79 | KLKB1 (0.47) | KLKB1GRM2NR1I2KCNH2 | |
| SCHEMBL28818254 | 0.78 | KLKB1 (0.53) | KLKB1ALDH1A1MAPTGRM2 | |
| SCHEMBL20481563 | 0.78 | ALDH1A1 (0.51) | KLKB1L3MBTL1ALDH1A1MAPTPKM | |
| SCHEMBL28008833 | 0.77 | KLKB1 (0.46) | KLKB1L3MBTL1 | |
| SCHEMBL1416055 | 0.77 | KLKB1 (0.55) | KLKB1L3MBTL1ALDH1A1MAPTGRM2 | |
| SCHEMBL27364065 | 0.76 | KLKB1 (0.41) | KLKB1L3MBTL1ALDH1A1MAPTPKM | |
| SCHEMBL28008344 | 0.76 | KLKB1 (0.48) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103080104-B | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides as inhibitors of plasma kallikrein | NOVARTIS AG | 2015-04-08 | — | — | CN | claimed |
| CN-103080104-B | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides as inhibitors of plasma kallikrein | NOVARTIS AG | 2015-04-08 | — | — | CN | disclosed |