Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28010850 | 0.78 | GAA (0.44) | PRKDCMTORMEN1KMT2APOLB | |
| SCHEMBL26581295 | 0.74 | SRD5A2 (0.62) | S1PR1S1PR5MEN1KMT2ANPC1 | |
| SCHEMBL14382486 | 0.70 | BMPR2 (0.46) | SPHK1PARP10SPHK2 | |
| SCHEMBL5526918 | 0.68 | CHEK2 (0.52) | PARP10 | |
| SCHEMBL21390699 | 0.67 | HRH3 (0.42) | PRKDCMTORHTR3AHRH3MEN1 | |
| SCHEMBL28331999 | 0.67 | PLA2G10 (0.48) | MEN1KMT2A | |
| SCHEMBL14382502 | 0.67 | BMPR2 (0.49) | SPHK1SPHK2 | |
| SCHEMBL4846094 | 0.66 | C5AR1 (0.47) | S1PR1S1PR5MEN1KMT2APARP10 | |
| SCHEMBL2361663 | 0.65 | HRH3 (0.49) | PRKDCMTORHRH3CYP2D6NPC1 | |
| SCHEMBL597702 | 0.65 | MEN1 (0.63) | S1PR1S1PR5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104603106-B | Indole carboxamide derivatives and uses thereof | 诺华股份有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-104603106-A | Indole carboxamide derivatives and uses thereof | NOVARTIS AG | 2015-05-06 | — | — | CN | disclosed |