Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391183 | 0.80 | CYP11B2 (0.46) | CDK4CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL21354754 | 0.79 | HTR3A (0.40) | MTORPRKDCALOX5APHTR3A | |
| SCHEMBL30315618 | 0.79 | HTR3A (0.40) | MTORPRKDCALOX5APHTR3A | |
| SCHEMBL24846738 | 0.77 | HTR3A (0.38) | MTORPRKDCALOX5APHTR3A | |
| SCHEMBL15252331 | 0.70 | CDK9 (0.50) | CDK4CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL25911521 | 0.68 | CYP3A4 (0.55) | PDE10ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL14293620 | 0.68 | MAPT (0.56) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL2361663 | 0.68 | HRH3 (0.49) | HRH3CYP2D6MTORPRKDCPDE10A | |
| SCHEMBL28010853 | 0.67 | PRKDC (0.47) | HRH3CYP2D6MTORPRKDCHTR3A | |
| SCHEMBL21017336 | 0.66 | CCNT1 (0.44) | CDK4CDK2CDK6L3MBTL1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |