Trimethylammonium

Trimethylammonium

SCHEMBL28014453

CN(C)C.O=C1CNc2ccccc21

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRPF1 P55201 1/20 0.42
SMN1; SMN2 Q16637 4/20 0.41
NOS2 P35228 1/20 0.40
ALDH1A1 P00352 5/20 0.40
MAPT P10636 5/20 0.40
ALOX15 P16050 3/20 0.40
HSD17B10 Q99714 2/20 0.40
CA12 O43570 1/20 0.39
CA9 Q16790 1/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
PDGFRA P16234 1/20 0.36
FER P16591 1/20 0.36
LTK P29376 1/20 0.36
CDK8 P49336 1/20 0.36
ACVR1 Q04771 1/20 0.36
LRRK2 Q5S007 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL68595 0.92 CA12 (0.45) BRPF1SMN1; SMN2NOS2ALDH1A1MAPT
Hydrochloric Acid SCHEMBL2034214 0.90 CA12 (0.43) BRPF1SMN1; SMN2NOS2ALDH1A1MAPT
Hydrochloric Acid SCHEMBL10863156 0.90 CA12 (0.43) BRPF1SMN1; SMN2NOS2ALDH1A1MAPT
Hydrochloric Acid SCHEMBL7397522 0.88 CA12 (0.42) BRPF1SMN1; SMN2NOS2ALDH1A1MAPT
Alcohol SCHEMBL27720735 0.85 BRPF1 (0.40) BRPF1SMN1; SMN2NOS2ALDH1A1MAPT
SCHEMBL17257956 0.83 CA12 (0.42) BRPF1SMN1; SMN2NOS2ALDH1A1MAPT
SCHEMBL27395617 0.83 ALDH1A1 (0.39) BRPF1SMN1; SMN2ALDH1A1MAPTALOX15
Water SCHEMBL27538247 0.82 ALDH1A1 (0.38) BRPF1SMN1; SMN2ALDH1A1MAPTALOX15
Water SCHEMBL27476632 0.82 ALDH1A1 (0.38) BRPF1SMN1; SMN2ALDH1A1MAPTALOX15
SCHEMBL9201794 0.79 MAOA (0.48) BRPF1SMN1; SMN2NOS2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104619701-A 2-oxo-2,3-dihydro-indoles for the treatment of cns disorders HOFFMANN LA ROCHE 2015-05-13 CN disclosed