Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6224233 | 0.81 | MEN1 (0.51) | KMT2ATSHRMEN1NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3332410 | 0.79 | KMT2A (0.44) | KMT2ATSHRMEN1NPC1ALDH1A1 | |
| Bromide SCHEMBL7986582 | 0.77 | MEN1 (0.51) | KMT2ATSHRMEN1NPC1ALDH1A1 | |
| SCHEMBL9189904 | 0.76 | CHRM1 (0.57) | KMT2ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL5760832 | 0.75 | KMT2A (0.44) | KMT2ATSHRMEN1NPC1ALDH1A1 | |
| Bromide SCHEMBL28502656 | 0.74 | LMNA (0.55) | KMT2ATSHRMEN1NPC1ALDH1A1 | |
| Bromide SCHEMBL3572191 | 0.72 | ALDH1A1 (0.55) | KMT2AALDH1A1LMNAL3MBTL1 | |
| SCHEMBL514540 | 0.71 | LMNA (0.60) | KMT2ATSHRNPC1ALDH1A1CYP2D6 | |
| SCHEMBL807415 | 0.69 | ALDH1A1 (0.66) | KMT2ATSHRALDH1A1KDM4ELMNA | |
| SCHEMBL11849104 | 0.69 | KMT2A (0.43) | KMT2ATSHRCYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103130739-B | There is the compound of thrombopoietin receptor agonism | SHIONOGI & CO., LTD. (JP) | 2015-09-16 | — | — | CN | disclosed |
| CN-102796058-B | Compound having thrombopoietin receptor agonism | SHIONOGI & CO | 2015-05-13 | — | — | CN | disclosed |