Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.52 |
| ▸ | PPARA | Q07869 | 9/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL238320 | 0.98 | PPARG (0.54) | PPARGPPARACYP2C9CYP2C19PPARD | |
| Bicarbonate SCHEMBL28016110 | 0.88 | MCL1 (0.51) | PPARGPPARACYP2C9CYP2C19PPARD | |
| SCHEMBL238319 | 0.87 | HDAC8 (0.54) | PPARGPPARACYP2C9CYP2C19PPARD | |
| SCHEMBL2291368 | 0.87 | ALDH1A1 (0.49) | PPARGPPARACYP2C9CYP2C19PPARD | |
| SCHEMBL238322 | 0.87 | MCL1 (0.52) | PPARGPPARACYP2C9CYP2C19PPARD | |
| SCHEMBL1156690 | 0.85 | ALDH1A1 (0.47) | PPARGPPARACYP2C9CYP2C19PPARD | |
| SCHEMBL30356799 | 0.84 | PPARG (0.62) | PPARGPPARACYP2C9CYP2C19PPARD | |
| SCHEMBL17942333 | 0.84 | PPARG (0.62) | PPARGPPARACYP2C9CYP2C19PPARD | |
| SCHEMBL236823 | 0.81 | FABP3 (0.53) | RAB9AL3MBTL1ALDH1A1KDM4ETDP1 | |
| Bicarbonate SCHEMBL27837013 | 0.81 | HDAC8 (0.62) | PPARGPPARACYP2C9CYP2C19PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105714282-A | Method and apparatus for producing polycarbonate | 拜尔材料科学股份公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-102102204-B | Method and apparatus for producing polycarbonate | BAYER MATERIALSCIENCE AG (DE) | 2016-04-27 | — | — | CN | disclosed |
| CN-105189445-A | Purification method of diphenyl carbonate for preparing high quality polycarbonate | SABIC INNOVATIVE PLASTICS IP | 2015-12-23 | — | — | CN | disclosed |
| CN-104640837-A | Process for the continuous manufacture of aryl alkyl carbonate and/or diaryl carbonate using vapor recompression | SABIC INNOVATIVE PLASTICS IP | 2015-05-20 | — | — | CN | disclosed |