SCHEMBL28016402

SCHEMBL28016402

Nc1csc(-c2cc(-c3cc(N)cs3)cc(-c3cc(N)cs3)c2)c1

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DYRK1B Q9Y463 4/20 0.35
DYRK1A Q13627 3/20 0.34
HSD17B1 P14061 1/20 0.30
HSD17B2 P37059 1/20 0.30
BRD4 O60885 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6068141 0.84 HSD17B1 (0.41) DYRK1BDYRK1AHSD17B1HSD17B2
SCHEMBL3246718 0.79 CDC7 (0.47) DYRK1BDYRK1A
SCHEMBL28175721 0.77 IKBKB (0.46) HSD17B1HSD17B2
SCHEMBL3082747 0.77 MAPT (0.44) HSD17B1HSD17B2
SCHEMBL30421266 0.77 IKBKB (0.49) DYRK1B
SCHEMBL19990277 0.77 HSD17B1 (0.55) HSD17B1HSD17B2
SCHEMBL4533436 0.74 AHR (0.48)
SCHEMBL27636869 0.73 CA2 (0.43) HSD17B1HSD17B2
SCHEMBL28148464 0.73 DYRK1B (0.69) DYRK1BDYRK1A
SCHEMBL28016403 0.72 CSNK2A1 (0.38) DYRK1BDYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104592069-A 1,3,5-tris(4-aminophenylmercapto)benzene as well as preparation method and application thereof UNIV JILIN 2015-05-06 CN claimed
CN-104592069-A 1,3,5-tris(4-aminophenylmercapto)benzene as well as preparation method and application thereof UNIV JILIN 2015-05-06 CN disclosed