SCHEMBL28016403

SCHEMBL28016403

Nc1csc(-c2ccccc2-c2cc(N)cs2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 1/20 0.38
PLK3 Q9H4B4 1/20 0.38
ALDH1A1 P00352 6/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
NPC1 O15118 4/20 0.35
RAB9A P51151 4/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
CYP3A4 P08684 3/20 0.35
TSHR P16473 2/20 0.35
TP53 P04637 1/20 0.35
MAPK1 P28482 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
PTPRC P08575 2/20 0.34
LMNA P02545 2/20 0.34
HPGD P15428 2/20 0.34
MEN1 O00255 1/20 0.34
APAF1 O14727 1/20 0.34
TDP2 O95551 1/20 0.34
NSD2 O96028 1/20 0.34
PLA2G1B P04054 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28750726 0.86 HTR2B (0.44) ALDH1A1L3MBTL1NPC1RAB9ASMN1; SMN2
SCHEMBL28988200 0.82 ALDH1A1 (0.41) CSNK2A1PLK3ALDH1A1L3MBTL1CYP3A4
SCHEMBL4489979 0.79 MAOA (0.48) CSNK2A1PLK3ALDH1A1NPC1RAB9A
SCHEMBL27692974 0.76 MAPT (0.49) ALDH1A1LMNAMEN1POLBKMT2A
SCHEMBL6873731 0.76 CASP1 (0.37) ALDH1A1NPC1RAB9ASMN1; SMN2CYP3A4
SCHEMBL5705050 0.74 CASP1 (0.42) ALDH1A1L3MBTL1NPC1RAB9ASMN1; SMN2
SCHEMBL28016402 0.72 DYRK1B (0.35) DYRK1BDYRK1A
Hydrochloric Acid SCHEMBL15910683 0.71 DYRK1B (0.33) CSNK2A1PLK3ALDH1A1SMN1; SMN2TSHR
SCHEMBL9519557 0.71 CD44 (0.37) CSNK2A1PLK3ALDH1A1CYP3A4TSHR
SCHEMBL6068046 0.71 MAOA (0.39) ALDH1A1SMN1; SMN2CYP3A4TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104592069-A 1,3,5-tris(4-aminophenylmercapto)benzene as well as preparation method and application thereof UNIV JILIN 2015-05-06 CN disclosed