Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6335393 | 0.86 | LMNA (0.38) | SCN9ALMNACYP1A2IDO1TDO2 | |
| SCHEMBL756557 | 0.83 | ARG1 (0.34) | SCN9AALDH1A1EP300HIF1ACREBBP | |
| SCHEMBL12332968 | 0.80 | MGAM (0.44) | SCN9AALDH1A1KMT2ALMNA | |
| Acetic Acid Methyl Ester SCHEMBL10879681 | 0.78 | ALDH1A1 (0.33) | SCN9AALDH1A1CYP3A4EP300HIF1A | |
| SCHEMBL697497 | 0.77 | — | — | |
| SCHEMBL2742122 | 0.77 | LMNA (0.52) | ALDH1A1CYP3A4MEN1MAPTKMT2A | |
| SCHEMBL24244322 | 0.76 | SCN9A (0.32) | SCN9AIDO1TDO2 | |
| SCHEMBL9132826 | 0.75 | LMNA (0.55) | ALDH1A1CYP3A4MEN1MAPTKMT2A | |
| SCHEMBL8895551 | 0.75 | LMNA (0.55) | ALDH1A1CYP3A4MEN1MAPTKMT2A | |
| SCHEMBL2900647 | 0.75 | LMNA (0.55) | ALDH1A1CYP3A4MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104619698-B | Pyrrolidin derivatives and the purposes as complement pathway regulator thereof | 诺华股份有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-104619698-A | Pyrrolidine derivatives and their use as complement pathway modulators | NOVARTIS AG | 2015-05-13 | — | — | CN | disclosed |